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Off-label use of medication can vary from being experimental or innovative or controversial to standard practice and even state-of-the-art treatment.
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The extent of lymphadenectomy remains controversial: compared to standard nodal dissection of perigastric nodes along the lesser and greater curvature, D2 lymphadenectomy is extended along the celiac axis, left gastric, common hepatic and splenic arteries.
The effectiveness of conical pedicle screws, in comparison to standard cylindrical screws, in osteoporotic specimens has been controversial.
However, adjustment for risk factors that are affected by the exposure (i.e., birth weight and BMI) is controversial because standard methods used to assess the direct effect of an exposure on a given outcome after controlling for an intermediate variable may result in bias (Cole and Hernan 2002).
It could also be the result of the WHO classification that is somehow controversial: this standard classification is said to suffer from a lack of reproducibility among pathologists [ 25].
The Texas state school board gave final approval Friday to controversial social studies standards that minimize the separation of church and state and say that America is not a democracy but a "constitutional republic". The changes, which passed in a series of 9 to 5 votes, could have reverberations far beyond the Lone Star State's schools and its 4.7 million students.
That was one of many controversial revisions to Texas standards.
It helps to understand how Internet radio royalties are set today: Royalty rates are established under a relatively new, controversial standard often referred to as the 'willing buyer-willing seller' standard, a standard that is ONLY applied to internet radio.
His thinking about theory and technique has been shaped by Charles Brenner, the intransigent purist of American psychoanalysis, author of a magisterial, impenetrable "Elementary Textbook of Psychoanalysis" and, with Jacob Arlow, of "Psychoanalytic Concepts and the Structural Theory," a once controversial, now standard advanced text.
Packed red cells volume is a controversial gold standard for anaemia, as it varies with different physiologic and pathologic conditions such as hydration status, and its correlation with haemoglobin is not optimal [ 12].
The White House has forced the Environmental Protection Agency to delay a costly and controversial new ozone standard.
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