Major ethical challenges of an FIH trial arise because of the indeterminate nature of the risks involved and the controversial risk-benefit justification.
It should be noted, however, that the presupposition that the structure of knowledge parallels the structure of justification is controversial.
Whether such recommendations have strong theoretical and empirical justification remains controversial [ 4, 5].
Besides, the kind of examinations for which both the contribution from private institutions and the variability was high fits well into this picture: examinations for which justification is controversial, e.g. knee [ 22] and spine [ 26, 27], and for which serious disease is seldom revealed.
In recent years, US officials have cited evidence that Awlaki had become personally involved in the planning of attacks on America – something that would help provide a legal justification for the controversial act of remote-controlled assassination.
This year's allocation shrank to 1.4bn rupees, yet smart cities remain a key justification for a controversial land-acquisition ordinance the government is aiming to enact, which does away with mandatory consent and social safeguards for those whose lands are forcibly acquired.
The White House on Monday suggested a fresh justification for the controversial prisoner swap it made to secure the freedom of US army sergeant Bowe Bergdahl, hinting that the deal may help restart broader Afghan peace talks as officials mounted a second attempt to win over sceptical members of Congress.
Both sides of any controversial issue can find textual justification for their positions, and there is enough ambiguity in certain constitutional phrases ("cruel and unusual punishment," "a well regulated militia") to fuel centuries of arguments.
One of the justifications for the controversial decision to cut the 50p tax rate next year was that it does not raise enough.
Mr Le Pen and Mr Gollnisch repeated their justification for making the controversial visit: that there are war criminals on both sides, notably the Americans who dropped atomic bombs on Hiroshima and Nagasaki.
