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These apparently paradoxical findings have shifted the attention from the controversial differentiation capacity of non-neural adult stem/progenitor cells (i.e., their potential to replace lost cells) to the mechanisms of intercellular communication between the transplanted and the host cells.
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Another controversial point is the differentiation between a bicornuate and a septate uterus.
The role of GSK3 β in regulating neural cell differentiation is controversial.
The effects of TH on keratinocyte proliferation and epidermal differentiation are controversial, with divergent results [8].
However, PLU1′s role in ES cell self-renewal and differentiation is controversial.
A similarly controversial issue is the differentiation of chondral injuries that require surgical procedure (debridement, microfracture or any other procedure) from those that should be considered merely osteoarthritic.
The origin of the tors has been controversial, but their emergence by differentiation after stripping of regolith during Pleistocene cold phases is accepted.
The exact requirements of individual cytokines or their combination for human Th17 differentiation are still controversial [7].
However, the role of FGF and fibroblast growth factor receptor (FGFR) signaling on hematopoietic and endothelial cell differentiation is still controversial.
In contrast, the contribution of Notch signaling to peripheral T cell differentiation remains highly controversial because different experimental approaches have resulted in strikingly different outcomes (Table S1)[29].
Interestingly, the Rac1-GEF P-Rex1 has been clearly involved in NGF-induced PC12 cell migration [34], but its role promoting neuronal differentiation is still controversial [37].
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