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These findings confirm that the deleterious effects of the E715K mutation cannot be accounted for even by the complete loss of phosphorylation and therefore support the model that E715 controls the conformational properties of Ire1.
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Our structural data suggest that Arg168 could function as a key residue controlling the conformational switch.
Wang and Oster proposed that interactions with the γ subunit would control the conformational and catalytic states of individual β subunits to sequentially generate torque.
In conclusion, we have shown structurally that ion binding and unbinding events in GltPh and, by analogy, in EAATs control the conformational state of the transporter, determining its competence to bind substrate and undergo transitions between the outward- and inward-facing states.
Modeling and simulation results are presented for an initial set of bio-molecules that illustrates a procedure through which optical excitation can be used to control the molecular conformational state.
At any given temperature, these factors are responsible for controlling the different conformational states of the MB with respect to random coil, stem-loop and bound-to-target [21].
Its association with coregulatory proteins occurs through interactions with the surface of the ligand binding domain (LBD) and is controlled by the conformational changes induced by ligands ultimately modulating gene expression [ 95].
Furthermore, the structure of the P. furiosus Rad50 ABC-ATPase with its adjacent coiled-coil defines a compact Mre11/Rad50-ATPase Mre11/Rad50-ATPasets that Rad50-ATP-driven complexandonal suggestsg directhatcontrols the Mre11 exonuclease.
The term "gating" was introduced at that time to describe this conformational process that controls the entrance and exit of a guest in synthetic host molecules.
The conformational changes experimentally observed in the enzymes by binding a broad range of ligands can be predicted by the most cooperative lowest frequency modes of motion by ANM, where the hinges are the key mechanistic regions of the structure that control the conformational ensemble.
Secondary structure controls the membrane potential and interrogates ion channels in different conformational states.
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