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RNA will be extracted from samples collected from identified cases (spontaneous preterm births with or without PPROM) and controls (term deliveries).
For example, in a study of the association between water disinfection by-products and preterm birth (gestational age at delivery < 37 weeks), Lewis et al. (2011) demonstrated that the shorter length of exposure in cases (preterm births) than in controls (term births) could bias associations with exposure during the third trimester.
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Healthy, untreated rats were used as normal controls (termed Fresh).
The +/Cre ARflox/y male offspring from these matings were termed "LCARKO," whereas the +/+ ARflox/y littermates were used as controls, termed "control".
A control term is readily added.
The first neural network estimates the equivalent control term and the other one generates the corrective control term.
However, a higher integral control term would create oscillations that are either unrecoverable or may throw the system to instability.
Further optimization is achieved by introducing a positive definite weight matrix that penalizes the quadratic control term.
The resulting protocol consists of a linear protocol and a nonlinear control term with adaptive update law at each node.
For compensate the reconstructive error of the RNN and the external disturbances, the robust control term is designed.
However, an additional robust control term is added to deal with sensor faults, approximation errors, and external disturbances.
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