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As little is known on how key pharmacokinetic parameters such as clearance change in morbidly obese children, adolescents, and adults as compared with their nonobese controls, studies are needed analyzing a wide range of ages and related TBWs.
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But such control studies are expensive, and therefore are rarely done.
Further epidemiological and case-control studies are warranted.
Patients treated with bosentan had higher survival rates, but prospective controlled studies are required to confirm these findings.
Randomized, controlled studies are required to confirm these results.
First, the majority of the approaches for case-control studies are based on single SNPs.
To help design altitude training protocols, data from more specific controlled studies are needed.
Further prospective, case-control studies are required in order to overcome these limitations.
However, randomized control studies are still needed (Class IIb, Level of evidence B).
Further prospective controlled studies are needed.
Results from case-control studies are inconsistent (reviewed in [ 14]).
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