Seven proteins in each subgroup of asthma showed significant differences with controls, separately.
On the other hand, after comparing expression correlation in cases and controls separately, a change in the complex network of protein interaction between ESR1, TNF, PGR and SYNE1 seems to be occurring.
The Hardy-Weinberg equilibrium test was performed in the cases and controls separately before association analysis.
Indeed, this is what we found when we re-configured our simulation data to run cases and controls separately, and re-analyzed it.
However when the CD or UC patient groups were compared to controls separately, significant more females were present in the group with Crohn's disease (p<0.01).
When analyzed these CpG sites in cases and controls separately, we observed differences in 44 CpG sites for PaC patients and 6 CpG sites for controls (Table S1).
This test calculates a global allele frequency based on the prevalence of the disease in order to calculate expected frequencies of each genotype in cases and controls separately, and a permutation test is used to determine the significance.
Allele and genotype frequencies were estimated by direct counting and deviations from Hardy-Weinberg equilibrium (HWE) were tested, in cases and controls separately, using the exact test as implemented in R Genetics package (version 1.2.1) [73].
This high prediction error rate is partly explained by the lack of any SNP-based rule for cluster B. Canonical discriminant analysis (CDA) was performed in CD patients and healthy controls, separately.
This methodology permits a more robust estimate of the influence of age and sex on angiogenin levels, as it uses approximately twice as many values (541 values) as would be used if considering cases and controls separately.
Looking at the kappa values of patients and controls separately, the results were fair to substantial.
