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The PDZ domain of EphB2 also controls localization of the AMPA-type glutamate receptor, while the ephrin binding domain of EphB2 initiates pre-synaptic differentiation (Kayser et al., 2006).
Since H1 controls localization of STAT92E in chromatin, we next asked if H1 and STAT92E physically interact.
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Controlled localization of class II MHC molecules is essential for proper class II MHC-restricted antigen presentation and the subsequent initiation of an adaptive immune response.
However, UNC-104 does not solely control localization of synaptic components such as UNC-10/RIM, UNC-13 and ELKS in C. elegans [26], and additional motors involved in transport of these proteins or other active zone proteins could also be perturbed in the tba-1 mutants.
10.7554/eLife.00291.011 Figure 9. Trafficking pathways controlling localization of endosomal TLRs.
Controlled localization of proteins to specific membranes at particular times is critical in the regulation of many intracellular processes.
As another control, localization of COPI (β-COP) on ERGIC membranes was not regulated by starvation or wortmannin.
Gleghorn et al. suggested that controlling localization of SZP in engineered cartilage may be critical for proper lubricating function [ 14].
Therefore, the ability to control localization of nanocrystals via self-assembly would be a valuable tool in the synthesis of nanocrystal/polymer composite particles.
To rapidly control localization of Tiam1, we designated three intracellular compartments as its transient hosts: the plasma membrane (PM), cytoplasm, and mitochondria.
Although there are sporadic reports that investigated the mechanism(s) that control localization of RBPs, a systematic approach to identify factors and pathways involved in this control has not been undertaken.
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