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Integrin recycling is becoming established as a crucial molecular mechanism that subtly controls cell migration, especially in pathological contexts [64].
In plasmacytoid, but not myeloid DCs, DOCK2 controls cell migration by functioning downstream of chemokine receptors and activating Rac [40].
It has been suggested that caspase-8 can contribute to cell motility and adhesion by regulating calpain activity which controls cell migration including rac activation and lamellipodial assembly [50].
A gradient of Wnt signaling controls cell migration along the AP axis in C. elegans [ 37].
While epithelial signaling by HGF-MET primarily controls cell migration and invasiveness, there is evidence that MET also drives cell proliferation (Gherardi et al., 2012).
The role of GlyR activation may be complementary to the one exerted by GABAARs, which controls cell migration termination (Bortone and Polleux, 2009).
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We also show the possibility to control cell migration by small pulsed currents.
In addition, roles of other kinases that may phosphorylate PDPN to control cell migration have not been investigated.
We thus concluded that the explant played the role of "cell reservoir", controlling cell migration up to a defined ratio of the initial explant volume.
Heterotrimeric G protein signaling is involved in many pathways essential to development including those controlling cell migration, proliferation, differentiation and apoptosis.
Before we can use mechanotaxis to control cell migration on a biomaterial surface, quantitative design criteria for a microelasticity gradient should be established.
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