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Sussman and colleagues discovered that the ubiquitin-specific protease 22 (USP22) is responsible for controlling the cellular transition from stemness towards differentiation [80].
Tip-based direct protein printing is a relatively new technique that is useful for controlling the cellular microenvironment with subcellular resolution.
The PLGA sandwiched cell/hydrogel construct was shown to be useful for controlling the cellular microenvironment and cellular behaviors such as growth, migration, proliferation and differentiation.
This chapter reviews the rationale for controlling the cellular microenvironment and the polysaccharides studied therein for ultimate use in tissue engineering and regeneration.
The overall message, says MIT molecular biologist Phillip Sharp, who moderated a press conference on miRNA: "MicroRNAs are key players in controlling the cellular properties of tumor cells and their study could provide critical insights for future treatment of cancer".
This study assessed the role of immobilized cell adhesion moieties on controlling the cellular attachment, adhesion and phenotype of cardiac muscle cells towards developing scaffolds for cardiac muscle tissue engineering.
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In later studies, the three scientists discovered that specific genes control the cellular death program in C. elegans.
Thus, artificial regulation of protein complex formation controls the cellular functions that involve protein complexes.
Although biomaterial-based matrices control the cellular behavior, these matrices are still far from being optimal.
An alternative approach is to control the cellular microenvironment through biomaterial-mediated sequestration of cell-secreted proteins important to differentiation.
Therefore, glycolysis and gluconeogenesis coordinate with the PPP to control the cellular production of NADPH and R5P and to determine which phase of the PPP is activated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com