Sentence examples for controlling the affinity from inspiring English sources

Considering that a single mutation of one aromatic amino acid lowers the processivity and increases hydrolytic activity in ChiA as demonstrated in the former biochemical study22, the balance between velocity and processivity is 'fine-tuned' by controlling the affinity with the substrates15.

Additionally, we found that syndecan-1 augmented cell adhesion to collagen by controlling the affinity state of the α2β1 integrin.

These data indicate that syndecan-1 modulates cell adhesion to collagen via the α2β1 integrin and suggests that this regulation occurs by controlling the affinity state of the integrin.

The use of simulations and docking experiments revealed that Lys23 is a critical residue for controlling the affinity of ADP for ANT1, with the acetylated system having a much lower binding affinity for ADP.

Based on the CT domain controlling the affinity of MCAK for microtubules redundantly with the C-terminal tail of tubulin, we hypothesized that this electrostatically charged CT region may play also a role in MCAK diffusion on the lattice and targeting to microtubule ends.

We also show that the MCAK C terminus controls the affinity of full-length MCAK for microtubules and reduces its association with the lattice to ensure maximal recruitment to microtubule ends, where MCAK can act as a depolymerase.

Since NFATc1/alphaA suppresses the RNA synthesis of secreted IgM and Blimp-1 but enhances Bcl-6 and Bach-2 RNA levels, NFATc1/alphaA appears to control the affinity maturation of Ig genes in germinal center (GC) B cells.

Fig. 1 C shows the residues of PDZ proteins 1BE9 and 2QKT at the positions controlling the ligand affinity.

First, the lower frequency of OVαβ TCR T cells as compared to MBPαβ T cells may play a role; second, the lower affinity of the OVαβ TCR may make it inherently less encephalitogenic; or third, regulatory T cells (presumably CD4+CD25+ T cells) might be more effective at controlling the lower affinity OVαβ T cells.

By looking at the parameters controlling the binding affinity of Gcn4p to the cis-regulatory elements of gene LEU3 and gene ILV5, we found that Gcn4p had close to 20% higher binding affinity to the binding site for gene ILV5.

Protein engineering is becoming increasingly important for pharmaceutical applications where controlling the specificity and affinity of engineered proteins is required to create targeted protein therapeutics.