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Therefore, by indirectly controlling the activity of the inhibitor Csk, Fyn may negatively regulate the activation threshold of αβ T cells [11].
While promoting the desensitization and endocytosis of membrane targets, β-arrestins have also been shown to activate downstream signaling cascades by locally controlling the activity of kinases (Src and MAPK) and other enzymes.
STAT5 has been shown to have a role in controlling the activity of factors that can contribute to its own activation.
A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein.
Another important general mechanism controlling the activity of transcription factors is posttranslational modification such as phosphorylation.
The next step for researchers was to discover what was controlling the activity of these genes in the blood.
Optogenetics has emerged in the past decade as a high-precision tool for monitoring and controlling the activity of nerve cells.
Our results exemplify a strategy for controlling the activity of laboratory-evolved RNAs in living cells.
Controlling the activity of T helper cell responses could be valuable for the treatment of autoimmune diseases.
Chemical genetics provides tools for controlling the activity of a selected enzyme in a dose-dependent and reversible manner.
In conclusion, our data suggest that both Sema3E and CXCL12 might cooperate in controlling the activity of ADF1/Cofilin and the intracellular signalling effects of CXCL12/CXCR4 on COS1 cells and most probably on CR cells.
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