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Moreover, the receptor concentration is revealed to be a key element in controlling signal transduction and we propose that its modulation constitutes a new way of controlling sensitivity to signals.
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Kelz, M. B. et al. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.
New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.
However, if one produces a device presenting controlled sensitivity to light, many other applications can benefit or can even be created.
To address whether Hrk1 controls sensitivity to polyene and azole drugs via the HOG pathway, we measured drug sensitivity of the hrk1Δ mutant.
Hrk1 is required for intracellular glycerol synthesis via the HOG pathway and thereby controls sensitivity to the antifungal drug fludioxonil (Fig. 4).
DOI: http://dx.doi.org/10.7554/eLife.04645.011 To test whether VEGFR3 levels control sensitivity to shear stress and vascular remodeling in vivo, we examined Danio rerio (zebrafish).
In both animals, this caused arteries to narrow, showing that VEGFR3 levels also control sensitivity to shear stress and hence vascular remodeling inside living creatures.
Since photoreceptors have been shown to control sensitivity to and utilization of carbon sources [ 83] the significant enrichment of ribosomal gene regulation likely reflects altered or decreased sensitivity to the extracellular carbon source.
Thus, to more completely understand factors that may control sensitivity to LT-induced cell death, we surveyed the expression of all three paralogs in LT-resistant and sensitive macrophages derived from a large set of mouse strains.
Our demonstration that fascin modulates BOS (Fig. 7N O) suggests that Drosophila genetics and neuron culture could be applied systematically to identify candidate genes whose human orthologs control sensitivity to statin-induced cognitive side effects.
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