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For the purpose of controlling matrix flowability, different dosages of HRWR admixture were introduced to a matrix with fly ash/cement weight ratio of 2.8 and water/cementitious material weight ratio of 0.23.
Temporal release and removal of select proteins (AzTMBmCh) was triggered with the application of thrombin and monitored in real-time with confocal microscopy, providing a responsive handle for controlling matrix properties.
also have important roles in controlling matrix structure and organisation [ 2].
In addition, the DDRs regulate extracellular matrix remodeling by controlling matrix metalloproteinase expression and activity.
In this aspect, controlling matrix proteolytic degradation and enhancing extracellular matrix (ECM) structure and its integrity are key steps towards curbing cancer invasiveness and tumor growth.
The use of these sequences offers substantive flexibility in controlling matrix degradation, as the substitution of amino acids in a MMP-sensitive peptide modifies degradation kinetics.
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Therefore, this transporter may be the primary mechanism by which the L-forms of ascorbic acid enter the chondrocyte to control matrix gene activity.
Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function.
Hence, serpin molecules may be potential therapeutic agents that could help control matrix degradation in OA.
Efforts have been largely disappointing due to lack of studies identifying the molecular/mechanical signals which control matrix repair and/or degradation in early disease states.
More work needs to be done to determine whether an increased collagen V deposition might represent compensation mechanisms to control matrix stiffness.
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