Sentence examples for controlling elements from inspiring English sources
She referred to Dissociator and Activator as "controlling units"—later, as "controlling elements"—to distinguish them from genes.
She considered mobile genetic elements as "controlling" elements in the genome because they altered the expression patterns of a particular genetic locus when they inserted into it.
When she compared controlling elements to the recently discovered repressor-operator system of E. coli (McClintock 1961), her interpretation was widely rejected because DNA mobility was not considered important to the short-term regulation of protein synthesis and genome expression.
Her work on controlling elements and gene regulation was conceptually difficult and was not immediately understood or accepted by her contemporaries; she described the reception of her research as "puzzlement, even hostility".
Based on the reactions of other scientists to her work, McClintock felt she risked alienating the scientific mainstream, and from 1953 stopped publishing accounts of her research on controlling elements.
Following Jacob and Monod's 1961 Journal of Molecular Biology paper "Genetic regulatory mechanisms in the synthesis of proteins", McClintock wrote an article for American Naturalist comparing the lac operon and her work on controlling elements in maize.
Although metabolic control is broadly distributed over all individual steps for a given pathway (352, 378), the most obvious targets for conceptual and experimental scrutiny involve major rate-controlling elements of pathways capable of supporting the anabolic and catabolic needs of rapidly proliferating cancer cells.
Riboswitches contain sensing "aptamer" modules, capable of ligand-induced structural changes, and downstream regions, harboring expression-controlling elements.
Moreover, it avoids the possibility of missing the identification of important variants in hitherto unstudied genes or regions of the gene-harbouring and gene-controlling elements.
Our structure shows that the Ezh2's methyltransferase domain forms a structural core with the two activity-controlling elements of PRC2, the WD40 domain of EED and the VEFS domain of Suz12 (Margueron et al., 2009; Schmitges et al., 2011).
Instead, she preferred 'controlling elements', a name obviously linked to her hypothesis, now discredited, that the main role of TEs was to regulate gene expression in an adaptive way.
