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The E2F3 transcription factor claims its role in controlling cell cycle progression.
Constitutively nuclear FoxO1 has been shown to suppress c-Myc expression as well as genes involved in c-Myc signaling, thereby controlling cell cycle and metabolism in ECs8.
One composed by genes specific for miR-34a activation ("34a-specific", 2039 genes) and enriched for pathways controlling cell cycle, checkpoints, E2F, and MYC targets (Supplementary Fig. 3c), which explain the anti-proliferative role of miR-34a in progenitor cells.
The ATM protein has been implicated in pathways controlling cell cycle checkpoints, radiosensitivity, genetic instability, and aging.
AHR signaling also affects cell death by regulating P53 signaling and controlling cell cycle gene expression.
It was recently reported that ANC1 mRNA splicing is regulated by Cdc40, a protein involved in controlling cell cycle progression [31].
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These data support a role for CD81 controlling cell-cycle and the number of RPE nuclei in the mouse retina.
Furthermore, its role in controlling cell-cycle progression during mitosis suggests that SIRT2 may be localized to mitotic structures [22], [23].
The 107 genes represent putative components of a regulatory network controlling cell-cycle quiescence during development.
The mechanisms controlling cell-cycle progression are highly conserved throughout eukaryotes.
This approach uncovered four distinct genetic pathways controlling cell-cycle entry during intestinal organogenesis.
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