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The extracellular matrix (ECM) plays a key role in tissue repair by controlling cell adhesion, motility, and growth.
Ng, C. C. A. et al. Using an electrical potential to reversibly switch surfaces between two states for dynamically controlling cell adhesion.
The nanoscale geometry and topography of the extra-cellular matrix (ECM) is an important parameter controlling cell adhesion and phenotype.
This original Pluronic patterning method should prove useful as a tool for controlling cell adhesion and directional movement in amoeba.
Finally, various classes of applications of nanotopographic patterning are discussed, including mechanisms for controlling cell adhesion and proliferation, alignment and differentiation, and functional tissue formation.
Agonist stimulation leads cells to regulate integrin affinity ("activation"), thus controlling cell adhesion and migration, controlling extracellular-matrix assembly, and contributing to angiogenesis, tumor cell metastasis, inflammation, the immune response, and hemostasis.
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Nanotopography controls cell adhesion, morphology and proliferation.
Using azobenzene-embedded self-assembled monolayers to photochemically control cell adhesion reversibly.
Previous studies have used strategies like enzymatic cleavage5, thermoresponsive polymers18, electroswitching19, photocleavage4,20,21,22, photoisomerization20 or host-guest displacement6,7 to dynamically control cell adhesion.
Such effects are normally orchestrated by signaling pathways that connect extracellular signals to the nucleus, regulating expression of genes that directly or indirectly control cell adhesion and growth.
Each integrin plays a specific role within a tissue type to control cell adhesion.
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