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Sustained activation of NMDA receptors (NMDARs) plays an important role in controlling activity of neural circuits in the brain.
I support this conclusion and propose that Shh signalling regulates retinal expression of p57kip2 by controlling activity of p53.
Previous reports have demonstrated the usefulness of magnetic nanoparticles for controlling activity of plasma membrane receptors or ion channels.
This suggests that access to an intracellular target could be a factor controlling activity of tricyclic compounds in the fascin bioassay.
p21Cip1/WAF1 protects cells against apoptosis through its CDK inhibitory activity, but also by controlling activity of transcription factors such as E2F1, c-Myc or STAT3.
Pharmacological hydroxylase inhibition with dimethyl-oxallylglycine (DMOG) activated NFκB signalling and defined a repressive role for prolyl hydroxylase (PHD -1 controlling activity of NFκB.
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To evaluate the potential of a particular protease as a drug target, use of a reagent that controls activity of the protease is indispensable.
These antibiotics are further distinguished by their novel mechanism of action in which they bind and deregulate the tightly controlled activity of the cytoplasmic protease ClpP.
Thus AP2C3 ability to control activity of MPK4 may lead to inactivation of this kinase in AP2C3oe plants resulting in cytokinesis defects.
It seems unlikely that this pathway controls activity of constitutive membrane recycling machinery such as Rab5 [38] but could act by coupling between E-cadh and this machinery.
Indeed, using cellular promoters to control activity of Cre is a frequently used approach to restrict recombination to cells in which that promoter is active.
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