Thus, on the one hand, Msh1 is a key player in the mitochondrial mutation avoidance system, and on the other hand, it is a chief controller of recombination processes in yeast mitochondria.
In this contribution, a novel approach to design gain-scheduled controllers of nonlinear processes is presented.
However, a relevant contribution to this regulation can be envisaged in the identified biological pathways related to the small GTPases RHO, RAC1, and CDC42 as they are known potential controllers of dynamic processes affecting the cytoskeleton such as the formation of stress fibers (RHO), lamellipodia (RAC1), and filopodia (CDC42) as well as membrane ruffling (RAC1).
Transcriptional network analysis identifies NF-κB, NEMO, Akt, PPARγ and SREBP1 as the key controllers of these processes and suggests that direct regulatory interactions between these factors may govern the transition from early (stressed, inflammatory) to late (pathological, steatotic) hepatic adaptation to HF feeding.
Furthermore, the 2-port control structure allows the transparent design of effective controllers for processes with non-minimum phase characteristics, or inherently unstable open-loop dynamics.
The design of robust controllers for processes with operating-point-dependent behaviour is a minimax optimisation problem which can, in general, e.g. for given controller structures or for practical relevant performance functionals, only be solved by numerical minimisation.
The findings showed that the faulty FTO gene 'switched on' two other genes – IRX3 and IRX5 – which have been identified as the "master controllers" of the process of thermogenesis as they can prevent the process in which energy is turned into heat, meaning it is instead stored as fat.
New explicit design relations for setting the controller parameters in PI control of industrial processes are proposed.
More precisely, in our solution the controller of the dissemination process, once trained, is able to select a proper number of content replicas to be injected in the opportunistic network to guarantee the timely delivery of contents to all interested users.
Cell-culture experiments on isolated monocytes demonstrated that resistin regulates proinflammatory cytokine secretion through the nuclear factor-κB pathway (22), a master controller of the proinflammatory process.
