Sentence examples for controlled phosphorylation of from inspiring English sources
pRB activity is modulated through the tightly controlled phosphorylation of Ser and Thr residues by cyclin-dependent kinases (CDKs).
RNAi-rescue and over-expression studies further demonstrated that both actin filament bundling and capping activities are important in regulation of leader bleb dynamics, and provided evidence that spatiotemporally controlled phosphorylation of Eps8 through Erk is important in coordinating these activities in cells.
ELKs are evolutionarily related to Eukaryotic Protein Kinases (EPKs) that regulate diverse cellular processes through the controlled phosphorylation of serine, threonine and tyrosine residues on protein substrates [ 3– 7].
Hyperphosphorylation of CKIε's C-terminus thus inhibits the binding of substrate proteins, and may act as a regulatory mechanism to control phosphorylation of targets.
Furthermore, it was shown that Rad17 ubiquitylation controls phosphorylation of Rad53, the yeast Chk2 orthologue, a downstream component of the DNA damage response [27].
The bacterial chemotaxis, which is mediated by two-component systems, directs motile cells to favourable environments by controlling phosphorylation of histidine kinase CheA and its cognate response regulator CheY.
ERG has previously been reported to control phosphorylation of GSK3β (Ser9) by regulating the WNT pathway [ 8].
A key question concerns the mechanism by which LRRK2 controls phosphorylation of Ser and Ser.
This requirement affords additional regulation of Smad3 activity to TGF-β, which has been shown to signal through cyclin-dependent kinases to control phosphorylation of T179 [ 27, 28].
The key finding of the present study is that the kinase activity of LRRK2 indirectly controls phosphorylation of Ser/Ser and hence 14-3-3 14-3-3 14-3-3ell as LRRK2 cytoplasmic localization.
This change in SMAD2P likely involves intermediate proteins or cellular events controlling phosphorylation of SMAD2, as we did not see changes in total SMAD2 (data not shown) with Hoxb5 manipulation or DHT treatment [ 51].
