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However, despite the documented harm of fluid resuscitation, survival in PRISM and VHS was better than expected when controlled for disease severity [ 4].
In additional analysis we controlled for disease duration, showing that this factor per se did not predict SIS, nor did it attenuate the significance of age as a predictor of SIS.
Therefore, to assess more precisely the effects of epoetin alfa treatment on QoL, these data were additionally examined by a priori-planned multiple linear regression analysis, which controlled for disease progression and other possibly confounding variables (e.g., demographic and baseline clinical characteristics).
Whilst we controlled for disease severity (recorded by baseline lung function) we did not control for other potential differences between trials which may impact on relative treatment effects (e.g. background therapy, history of exacerbations) as reporting was less consistent for these indicators.
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We may have inadequately controlled for disease-related (silent ischemia, CHF and COPD exacerbations, and medication use) and non-disease related factors (stress, depression) that are known to transiently increase the levels of inflammatory and thrombotic markers independently of PM effect.
The study found a higher incidence of severe heart disease in children from low-income neighborhoods, but the neighborhood effect remained after controlling for disease severity.
This study tested the relationship between metacognitive factors, intolerance of uncertainty, anxiety, and the predictability of, and distress associated with, acute fluctuations in symptoms in idiopathic Parkinson's disease (PD), when controlling for disease parameters.
Symptom scores remained associated with functional outcomes after controlling for disease score and demographic variables.
After controlling for disease severity, there was a significant interaction between age and hostility.
The relation of type A behavior to survival was tested using data from coronary angiography to control for disease severity.
CONCLUSIONS: This study shows differing diseases indeed have unique disability fingerprints, which remain unique after controlling for disease duration and for population-specific differences in physical impairment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com