And how do you control escalation?
This means any Indian military action comes with a risk of serious — and potentially difficult to control — escalation of hostilities between the two nuclear-armed foes.
Countries tend to use them only if they can control escalation, while desperate countries fear the repercussions.
Former Secretary of Defense William Perry, a sage on these matters, has summed up the danger: the smaller-yield nuclear arms could make the unthinkable more likely: "They make the weapons seem more usable even if there's no credible plan for how you control escalation".
We then analyze the reasons why unescalatable locks are generated and propose a new lock escalation method, adaptive lock escalation, which controls lock escalation based on the number of unescalatable locks.
Despite limited exposure (median 36 weeks), this analysis demonstrates that escalation of deferasirox to doses of >30 mg/kg per d effectively decreased serum ferritin compared with levels prior to dose escalation in patients whose serum ferritin levels were not adequately controlled before escalation.
Protocol 1 assessed the response to inhaled revatropate (1, 2 and 7 mg) using a blinded, negative (inhaled saline) and positive (inhaled ipratropium bromide; 0.3, 0.7 and 2 mg) controlled, dose escalation study, with six heaves horses.
A phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria.
The study was a double-blind, randomized, controlled, dose escalation phase Ib trial (www.clinicaltrials.gov NCT00452088) designed to assess the safety, reactogenicity and immunogenicity of three injections of either 15 µg or 30 µg of MSP3-LSP adsorbed on aluminum hydroxide in children 12 to 24 months of age.
