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The course staff does not control enrollment!
This trend subsided somewhat in the 1990s due to attempts to control enrollment and increased fees at public universities.
Only one of these trials included patient with brain metastases and the CNS disease had to be controlled for enrollment 8.
To be consistent in the treatment of cases and controls, a child who was previously a case may be enrolled as a control if the control enrollment date is >30 days after the date of hospital discharge from the previous case episode.
In Dhaka, Bangladesh, community control enrollment was >95% in previous studies [ 7– 9].
Community control enrollment achieved sufficient numbers, but required additional expense and logistical coordination.
If a control develops severe or very severe pneumonia within 48 hours of their control enrollment date, this control enrollment will be excluded, but the child would be eligible to be a case.
The Mayo Clinic case and control enrollment research protocol was approved by the Mayo Clinic's Institutional Review Board (13).
Additional details of case and control enrollment, laboratory methods, and statistical analysis are provided in the Supplementary Data.
Sample size for only one other study was larger than the case and control enrollment in our own study [ 8].
The median interval between case specimen collection and control enrollment was 30 days (IQR, 4 144) for HIV-uninfected and 84 days (IQR, 9 276) for HIV-infected controls.
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