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MiRNAs control the timing of development in C. elegans and other animals [32].
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Imagine that the timing of development is controlled by two knobs like you'd find on a radio.
Characterization of genes that control the timing of larval development in Caenorhabditis elegans revealed two small regulatory RNAs, lin-4 and let-7 (Reinhart et al., 2000).
We used immunohistochemistry and cDNA microarrays to examine expression of selected survival-associated genes and Id4, a gene believed to control the timing of oligodendrocyte development.
MrpC governs the timing of development.
The timing of development of a latent MTrP may differ from muscle to muscle.
These data suggest that intracellular levels of c-di-GMP influence the timing of development.
It is these temporal structures that allowed a quantitative assessment of the timing of development.
The first characterized endogenous miRNAs were lin-4 and let-7, both of which were shown to act in the pathway controlling the timing of larval development in C. elegans [4], [5].
Because of difficulty in controlling the timing of ookinete development and mosquito infections, only a few events were captured that could facilitate detailed description (n = 4).
Since the identification of the first microRNAs (miRNAs) as key regulatory molecules in the pathway controlling the timing of larval development in Caenorhabditis elegans [ 1], great progress has been made in the understanding of miRNA function in various species.
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