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Genes involved in IFN-activated pathways that control the survival of lymphocytes have been strongly linked to lupus susceptibility, and IFN-mediated defenses against viral infection have been shown to determine susceptibility to a model of viral-induced diabetes.
Understanding the factors that control the survival of these pathological B cells is essential for elucidating the pathogenesis of SLE (reviewed in [1], [2]) and providing new targets for SLE therapy (reviewed in [3], [4]).
By contrast, little is known about the factors that control the survival of these cells.
Here we integrated host phosphatases into a host kinase network that both control the survival of intracellular bacteria such as Salmonella.
50 70% of freshly isolated granulosa cells from patients undergoing assisted reproduction contained cells which stained positively for c-Kit [ 80]. c-Kit signalling is likely to control the survival of human ovarian follicles during early follicular development.
Remarkable and certainly worth some scrutiny is the newly emerging information showing that the oestradiol ER complex may not only control the survival of the breast cancer cell but also induce its death following exhaustive endocrine therapy.
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Our data provide evidence that Nestin controls the survival of neuronal progenitor cells (NPC).
Alternatively, the observed resistance to Plasmodium expansion could be mediated by a hepatocyte factor that controls the survival of infected hepatocytes, for example sporozoite mediated inhibition of hepatocyte apoptosis.
In sum, we propose that Ambra1- and Beclin 1-mediated autophagy plays a crucial role in adult neurogenesis, by controlling the survival of neural precursor cells.
To the best of our knowledge, this is the first study to explore the role of RLRs in controlling the survival of MSCs, which may provide a clue to understand the pathogenesis of viral infection in MSCs.
Mesenchymal survival remains an important issue, and further research toward controlling the survival of these cells should eventually result in the development of effective treatments for lung fibrotic diseases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com