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A number of criticisms of this position have been put forward, based on issues such as the difficulty of designing a placebo-like control, the impossibility of maintaining double-blind conditions, the challenge of standardizing interventions, the importance of the therapist-patient fit, and the reduced external validity of psychotherapy in the context of a RCT [ 3].
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His remarks concerning the impossibility of controlling the passions and the desirability of controlling them nevertheless to the extent that we can (V Preface) similarly emphasize the ethical importance of self-knowledge and freedom from external influences.
Catastrophising cognitions are exclusively focused on pain: a negative vision of it (magnification), continuously thinking about it (rumination) and the impossibility of controlling it (helplessness).
His lack of ambition, and inclination to drift into semi-catatonic trances, sabotaged all attempts to further his career, whether by Jamison or by Otis Redding's management team, which briefly assumed control of his affairs, before recognising the impossibility of the task.
Instead they will highlight the limitations of all these things: the boundaries of our knowledge, the complexities of accountability, and the impossibility of absolute control.
However beyond confirming blood glucose control matters, that is not clinically useful because of the impossibility of understanding how long such control has to be maintained to gain the benefit.
We were surprised by the degree of consensus on the need for reform of drug policy; the fact that the Misuse of Drugs Act 1971 simply cannot cope with the modern polydrug culture; and the impossibility of effectively controlling the supply of "legal highs" using existing legislative instruments.
Perhaps most daunting is the sheer weight of state control in the Eastern European economies and the impossibility of tilting the balance quickly toward private enterprise.
The lives he is drawn to depicting, in this novel and the first one, seem all about control, the need for it, and ultimately the impossibility of it.
Anyhow, we should assume that unintentionally defected GNRs are present from the phase of production due to the impossibility of an accurate control of purity at an atomic level.
In the United States, Doris Meissner, formerly head of the Immigration and Naturalisation Service, recalls with frustration the impossibility of enforcing effective controls on employers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com