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Broader surveys of NPC1 orthologs from vertebrates may delineate additional sequence polymorphisms in this gene that control susceptibility to filovirus infection.
While it is widely known that immune-system genes influence susceptibility to cancer, learning that they may also control susceptibility to a parasitic disease was "quite interesting," Dr. Donnelly said.
For example, a participating group of researchers from Rockefeller University led by Drs. Jean-Laurent Casanova and Laurent Abel have found a gene that appears to control susceptibility to reactivation of TB infection in young adults.
Animal models have been useful in identifying self-antigens that become the focus of autoimmune attack and genetic loci that control susceptibility to disease.
"They show that just one mutated gene can control susceptibility" to severe flu.
Disease-promoting and disease-protecting genes within the Eae39 locus on mouse chromosome 5 control susceptibility to CIA.
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The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi.
Dorhoi A, Iannaccone M, Farinacci M, Fae KC, Schreiber J, Moura-Alves P et al. MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
Smith, K. A. & Maizels, R. M. IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo.
Here we report a new, unexpected role for PLEKHA7 and several components of cellular adherens junctions in controlling susceptibility to S. aureus α-toxin.
In summary, we have identified five novel QTLs controlling susceptibility to radiation-induced polyposis in ApcMin/+ mice.
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