Sentence examples for control protrusion from inspiring English sources
PTEN is known to control protrusion formation and adhesion during cell migration [34] via modulating actin dynamics [35].
We find that alterations in EphB2 signaling can bidirectionally control protrusion length, and knockdown of EphB2 expression levels reduces the number of dendritic spines and filopodia.
By studying the effects of p27WT protein on the regulation of glioblastoma cell growth and motility we observed that the WT protein was able to stimulate the formation of neuron like protrusions in U87MG cells (Video S1), thus confirming our previous observation that p27 is able to control protrusion formation in 3D context [24], also in glioblastomas.
Left, the jaw-closing masseter muscle; right, the genioglossus: a muscle of the tongue controlling protrusion.
Lamellipodin (Lpd) is known to control lamellipodia protrusion by regulating actin filament elongation via Ena/VASP proteins.
Because Rho kinase inhibition of SW480 migration on LN is fascin-1-independent [ 5], it is likely that control of protrusion number has a multifactorial basis, for example, it may be linked to both actomyosin-based cell tension and chemical signaling.
The regulation of Src activity by RACK1 is also required for modulating paxillin during cell migration [ 182], for regulating Sam68 and p190RhoGAP signaling [ 183], to control cell protrusion during cell migration [ 168] and for regulating cell cycle checkpoints [ 62, 114, 139].
Gabella, C. et al. Contact angle at the leading edge controls cell protrusion rate.
Actin regulators facilitate cell migration by controlling cell protrusion architecture and dynamics.
The inhibited RhoA activity at cell migration direction can lead to the activation of Rac1 [42], a small GTPase controlling cell protrusion and lamellipodia formation [43].
Future studies benefiting from the enhanced understanding of the mechanisms of bleb formation will help understand how modulation of cellular and environmental properties controls the protrusion type formed during migration in specific contexts.
