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This lower dose could be expected to be less effective, but the actual difference in outcome depends on steepness of the tumour control probability curve.
However, the effect of microscopic disease and RT dose on tumor control probability (TCP) was seldom studied quantitatively.
Cervical cancer brachytherapy has an effective role on the tumor control probability as a boost and/or single treatment option.
Recent findings from preclinical studies have demonstrated the predictive potential of DDR foci by correlating foci with clinically relevant end points such as tumor control probability.
The study was designed to propose a novel concept of biologically effective equivalent uniform dose to calculate tumor control probability for HDR implants.
To evaluate the doses in the phantom, a comparison of the different assemblies and beam energies was done using a Tumor Control Probability (TCP) model.
This study investigates the relationship between contouring variation, tumor control probability (TCP) and equivalent uniform dose (EUD) for conformal non-small cell lung cancer (NSCLC) radiotherapy.
We compared dosimetry and radiobiologic model predictions of tumor control probability (TCP) and normal tissue complication probability (NTCP) for prostate cancer patients planned for IMRT as opposed to standardized three-dimensional conformal radiotherapy (3DCRT).
In detail the GEANT-3/MICAP simulations show that high tumor control probability, with sub-lethal dose at healthy tissues, can be achieved by using neutron beams of few keV energy having a flux of about 109 neutrons/(cm2 s).
Results: Data are presented for the conventional regimen of 50 50.4 Gy in 25 28 fractions in 5 6 of weeks preoperative external beam RT with respect to the regimen's local control probability compared to surgery alone, as well as acute and late toxicities.
The analysis of the therapeutic gain shows that a high tumour control probability with sublethal dose at healthy tissues can be achieved, in most cases, by using neutron beams of a few keV energy, with a flux of about 109 neutrons/cm2 s.
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