Sentence examples for control phosphorylation of from inspiring English sources

Hyperphosphorylation of CKIε's C-terminus thus inhibits the binding of substrate proteins, and may act as a regulatory mechanism to control phosphorylation of targets.

Several of these changes affect the kinase cascades that control phosphorylation of Myc.

ERG has previously been reported to control phosphorylation of GSK3β (Ser9) by regulating the WNT pathway [ 8].

In comparison to the control, phosphorylation of Smad2 was elevated in hepatic stem-like cells, small hepatocytes and mature hepatocyte-like cells derived from SSCs.

This requirement affords additional regulation of Smad3 activity to TGF-β, which has been shown to signal through cyclin-dependent kinases to control phosphorylation of T179 [ 27, 28].

The founding member, mammalian MAST2, was originally found to co-fractionate with microtubules and to bind and control phosphorylation of the tumour suppressor PTEN and the Na+/H+ exchanger NHE3 (SLC9A3) (Walden and Cowan, 1993; Valiente et al., 2005; Wang et al., 2006).

The PI3K/mTOR signaling pathway controls phosphorylation of 4E-BP1 and S6K, and S6K1 also phosphorylates S6, and has been proposed to phosphorylate EF2K and pdcd4, controlling the activity of S6 and EF2K, and protein stability of pdcd4 [ 20, 30- 32].

Furthermore, it was shown that Rad17 ubiquitylation controls phosphorylation of Rad53, the yeast Chk2 orthologue, a downstream component of the DNA damage response [27].

The bacterial chemotaxis, which is mediated by two-component systems, directs motile cells to favourable environments by controlling phosphorylation of histidine kinase CheA and its cognate response regulator CheY.

A key question concerns the mechanism by which LRRK2 controls phosphorylation of Ser and Ser.

pRB activity is modulated through the tightly controlled phosphorylation of Ser and Thr residues by cyclin-dependent kinases (CDKs).