In agreement with the increased burden of misfolded proteins, e.g., upon cigarette smoke exposure, protein quality control pathways are mainly activated in adult chronic lung diseases.
The logic of the design and methods described can be modulated and used for the identification and analysis of novel RNA quality control pathways in other organisms.
These results reveal the relevance of cell cycle control pathways in the cytotoxicity induced by the TK/GCV system identifying candidate genes as conditioners of TK/GCV sensitivity.
Protein quality control pathways are not only activated as an adaptive response to altered proteostasis, but they may also be direct targets of noxious environmental exposures as recently shown for the proteasome.
Among these interactions are DNA repair pathways involving RAD50, 51, 54, MCM2, 5, 6, UVH1, MRE11, and others; Cell cycle control pathways with CDC2, cyclin dependent kinases, SNF1-related protein kinase; and the transcription initiation complex.
Work which elucidates replicative control pathways thus also has a high likelihood of generating important information relating to the ageing process, an area in which I have a particular interest.
The sustained attention task used in the current study required the unique activation of alerting, orienting and executive control pathways, which is a variation from more commonly used tests of sustained attention such as the rapid visual information processing task.
So we fight to end drug prohibition and replace it with sensible drug policies, the most sensible of which is regulation as recommended in the esteemed Global Commission on Drug Policy report "Taking Control: Pathways to Drug Policies That Work".
Numerous components of apoptotic and cell cycle control pathways were differentially expressed, including p27KIP and TFs that regulate its expression.
One such protein is ataxin-3, a protein implicated in protein quality control pathways and transcriptional regulation [11].
Several studies indicate that mRNAs in the same pathways share similar decay kinetics and could share overlapping stability control pathways [18].
