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There have been recent advances in the understanding of protein interactions involved in MCP assembly, the application of encapsulation-mediating peptides to model cargos, and control over loading of such cargos.
Milligram/cm2 scale linear or power law release profiles can be achieved over 2 to 34 days, and control over loading and release are demonstrated through parameters such as tuning the degradability of the synthetic polycation, changing the number of layers used, or changing the polysaccharide polyanion.
(16 ) Both mRNA and miRNA found in extracellular vesicles are in different relative proportions compared to their parental cells, 17 ) suggesting that there may be some control over loading of RNAs.
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The piezoelectric-driven mechanism allows the precise adjustment and control over load-related deformations of tissue, as shown by finite-element calculations of deformation of a collagen gel under load.
With the increasing presence of intermittent renewable energy generation sources, variable control over loads and energy storage devices on the grid become even more important to maintain this balance.
The bioreactor allows for simple control over the loading parameters with a user-friendly graphical interface and is equipped with a load cell for monitoring tissue maturation.
Aryal, S., Hu, C. M. & Zhang, L. Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.
A critical element in the design of custom biosynthetic organelles is quantitative control over the loading of heterologous enzymes to the interior of the organelles.
These films provide the level of control over drug loading and release kinetics required in medically relevant applications including coatings for implant materials and bandages, while eliminating susceptibility to bacterial resistance.
These strategies allow general control over the loading of heterologous proteins localized by two different N-terminal targeting peptides and represent an important step toward tuning the catalytic activity of bacterial microcompartments for increased biosynthetic productivity.
Furthermore, a Field Programmable Gate Array (FPGA) was used to implement an embedded hardware/software solution and interface to enable real-time control over embryo loading and immobilization; accurate microfluidic flow control; temperature stabilization and also automatic time-resolved image acquisition of developing zebrafish embryos.
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