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Aryal, S., Hu, C. M. & Zhang, L. Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.
These films provide the level of control over drug loading and release kinetics required in medically relevant applications including coatings for implant materials and bandages, while eliminating susceptibility to bacterial resistance.
Along with providing control over drug loading and release, the GO nanosheets create a unique opportunity to alter the morphological characteristics of the nanocomposite film.
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Altogether, these novel microneedle designs provide a new set of tools to fabricate dissolving polymer microneedles with improved control over drug encapsulation, loading, and delivery.
These systems offer narrow particle size distribution, biocompatibility, good stability, prolonged blood circulation times, high drug loading, and control over drug release rate, in addition to superparamagnetic behavior for MRI contrast.
The collaboration with academic institutions and other drug testing companies gave control over drug trials to private drug companies.
Conjugation of drug molecules to the polymer backbone allows for precise drug loading and control over release kinetics.
Moreover, LB-MSNPs hold several advantages over liposomes, including drug loading capacity, stability, and the ease of achieving multifunctionality.
Each micelle comprises ∼90 lipid molecules, and their relative monodispersity allows for incorporation of precise numbers of functionalized lipids per particle to provide control over the valency of the targeting peptide and drug loading.
Alginate-poly (lactic-co-glycolic) acid (alginate-PLGA) core-shell microparticles are promising drug carriers with high loading efficiency for hydrophilic drugs and good control over the drug release kinetics.
Alternatively, small-scale drug loading in control or AH vaults was conducted in a semianalogous manner.
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