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This approach could be further improved if the controlled delivery of bioactive rhBMP-2 were sustained throughout the duration of osteogenesis from fibrous scaffolds that provide control over dose and bioactivity of rhBMP-2.
Our results demonstrate that Nanog protein transduction is an attractive tool allowing control over dose and time of addition to the cells for studying the molecular control of pluripotency without genetic manipulation.
In addition, the co-administration of drug products with food or drinks causes safety concerns, such as poor control over dose intake and impact on drug's bioavailability [46].
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This dosing method permits precise control over dosing during gestation and lactation where food or fluid intake can vary significant.
In mice, we have maximal control over dosing and are assured of treatment compliance; in humans, neither of these is true.
As a result of its adjustable properties, stability, and fine control over dosing, the novel GO nanocomposite release platform described here has the potential to advance these drug delivery technologies by enabling tailored drug-release profiles.
The increase in released FDA with irradiation time, as indicated by fluorescence of its cleaved product, indicates tunable control over the dose of cargo released.
In order to avoid the fluctuations in power of an arc lamp source, a microscope using a light emitting diode that was calibrated accurately at low power levels, was constructed to provide good control over the dose of light applied to the biological specimen.
Therefore, in patients suffering from moderate-to-severe pain in the hospital setting, providing the flexibility of patient control over opioid dosing should remain a goal of postoperative analgesia for both increased patient satisfaction and better analgesic efficacy.
Escalation with over-dose control (the EWOC) is a Bayesian adaptive Phase I clinical trial design that can accurately estimate the maximum tolerated dose (MTD) level and control the probability of overdosing patients during the dose allocation phase.
Furthermore, when simultaneously express multiple different proteins, mRNA vectors allow for greater flexibility and control over stoichiometric ratios, dose titrations, and complete silencing of expressions.
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