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Control of the ionisation process is effected through the operating conditions within the interface.
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For heavier ions zp > 6 the resolution is limited by the statistical nature of the ionisation process in the counter gas.
More strictly the rate at which the electron tunnels through the barrier associated with the Stark saddle point must be considered in a complete description of the ionisation process.
However, for undiluted samples, SSE values between 88 and 144 % (RSD ≤ 5 %, n = 3) were observed due to matrix components which affect the ionisation process of the coeluting metabolites of interest (see ESM Table S12).
Matrix effects are caused by the suppression or enhancement of the analyte signal during the ionisation process and may hamper the accurate quantification, leading to incorrect results.
The change from UV to MS detection requires a significant change in approach since the use of MS poses a number of unexpected problems and limitations which relate to instrument design and the ionisation process.
Remain in control of the catering process.
First, control of the process is crucial.
We're taking control of the process".
During breath-by-breath data acquisition it appeared clearly that some competition between volatiles towards the chemical ionisation process occured.
Although fewer peptide ions are detected, due both to the steric constraints imposed by the virion that impedes digestion and the competitive ionisation processes when large mixtures of peptides are analysed, all four antigens are represented in the spectrum.
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