Sentence examples for control of pathway from inspiring English sources
Hence, the metabolic engineering challenge was not to improve titer, but to enable precise control of pathway state.
This knowledge gap is a limiting factor in the application of engineered protein-level regulation in Metabolic Engineering for the rational and sensitive control of pathway flux.
As metabolic engineering expands its applications and develops more complex systems, tight control of system components will likely become increasingly necessary, and the approach presented here can be generalized to other natural sensing systems for precise control of pathway state.
The selection of a key thiolase (bktB) and thioesterase (ydiI) in combination with previously established core β-oxidation reversal enzymes, as well as the development of chromosomal expression systems for the independent control of pathway enzymes, enabled the generation of C6 C10 carboxylic acids and provided a platform for vector based independent expression of ω-functionalization enzymes.
Metabolic Control Theory [ 26] has demonstrated that tighter control of pathway fluxes can be maintained by regulation of demand than supply, i.e. near the end of a pathway.
The enzyme phytoene synthase (PSY) catalyses the first committed step of the carotenoid biosynthetic pathway and has been associated with control of pathway flux.
Metabolic control analysis (MCA) has shown that control of pathways and cellular processes is distributed among several participants and, hence, there are not single rate-limiting steps.
These data indicate that fibrotic fibroblasts manifest pathological control of pathways governing proliferation, viability, motility, contractile function and connective tissue production.
However, genetic control of pathways determining gout in the presence of hyperuricemia is still poorly understood.
Therefore, it is not too surprising that control of pathways generating and using nitrogenous precursors might share similarities on the one hand and exhibit distinct differences on the other.
The existence of several microRNAs that converge on the NF-κB pathway suggests that tight control of this pathway is crucial for the maintenance of vascular homeostasis.
