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These data argue against a direct control of miRNA expression by Aire.
AtPHR1 binds the promoter region of miR399 in Arabidopsis [ 30], indicating control of miRNA expression by TFs.
As discussed below, each step of the general biogenesis pathway has been found to be differentially regulated to allow exquisite control of miRNA expression.
These mechanisms provide an important method for the control of miRNA expression during development, and deregulation of these processes is likely to contribute to multiple pathological outcomes.
Furthermore, the application of chromosome conformation capture technology may facilitate the identification of long-range regulatory elements (e.g., enhancers and silencers) that contribute to the control of miRNA expression, and may also harbor trait/disease-causing genetic variants.
The post-transcriptional regulation adds another layer of control of miRNA expression during an innate immune response, enabling selective modulation of levels of certain mature miRNAs, and ensuring miRNA-mediated regulation to be exerted more precisely, as in the case of KSRP-promoted maturation of miR-155 during pDC activation.
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These data indicate that a previously unknown regulatory relationship for miR-146b-5p miR-146b-5p miR-146b-5povexpressionalyzing the couldlation between miRNA and mRNA profiles in single cells, and suncoveredrole for AKT to control intercellular variabylity of miRNanalyzingion.
Colangelo, V. et al. Next-generation sequencing analysis of miRNA expression in control and FSHD myogenesis.
Further indirect evidence of active posttranscriptional gene control in chondrocytes comes from studies of miRNA expression in chondrocytes.
Transcriptional regulation by nuclear receptors is the primary level of control for miRNA expression (Table 1).
It is also worth noting that, although it is generally believed that the changes of miRNA expression are controlled at the level of transcription, proteins that are involved in generating miRNA from its precursor can also exert their influences.
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