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The effects of GIK infusion may extend beyond control of hyperglycaemia alone [ 4].
The presence of pre-existing diabetes mellitus or post-neurosurgical status often prompted more intense control of hyperglycaemia.
Nevertheless, it remains possible that control of hyperglycaemia by insulin infusion with a glycaemia focus improves mortality after AMI.
Simultaneous control of hyperglycaemia, hypertension and dyslipidaemia is, therefore, essential for reducing the risk of complications in patients with T2DM.
These findings suggest that current guidelines for the detection and control of hyperglycaemia and GDM in South Asian women should be rigorously applied.
Intensive control of hyperglycaemia retards diabetic microvascular complications (e.g. retinopathy, nephropathy and neuropathy) [ 5], but beneficial macrovascular effects (coronary atherosclerosis) are less apparent [ 6].
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More and more researches suggested that the multi-target therapy combining with the control of postprandial hyperglycaemia and oxidative stress may become a promising therapy strategy because oxidative stress is mainly induced by postprandial hyperglycaemia [ 4].
However, accumulating evidence indicates that control of postprandial hyperglycaemia is also important in achieving HbA1c goals [ 30].
Control of postprandial hyperglycaemia is believed to have more of an impact on both micro- and macrovascular risk factors than reduction of elevated fasting glucose levels [ 15].
Furthermore, control of postprandial hyperglycaemia with repaglinide resulted in regression of carotid intima thickness and reductions in markers of systemic inflammation [8].
Notably, lixisenatide's improved control of postprandial hyperglycaemia occurred without increased risk of hypoglycaemia, which can be an issue with rapid-acting insulins.
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