Sentence examples for control of gene activation from inspiring English sources

Skeletal development and bone remodeling require stringent control of gene activation and suppression in response to physiological cues.

In the present study, by exploiting the Cre-lox mediated intrachromosomal recombination and implementing a novel mechanism to control the stochastic level, we developed a new strategy for purely genetic control of gene activation with desired sparseness.

We demonstrate that these ligand-responsive TALE transcription factors allow for tunable and conditional control of gene activation and can be used to regulate the expression of endogenous genes in human cells.

It remains a challenge to establish a straightforward genetic approach for controlling the probability of gene activation or knockout at a desired level.

This poses two technical challenges to molecular geneticists: first, how to manipulate gene activation in a stochastic way; second, how to control the stochastic level of gene activation.

Thus, by varying the length of one unit while keeping the other constant, we can regulate the probability of the desired recombination, and control the sparseness level of gene activation.

A major advantage of STARS is to be able to regulate the level of sparseness through controlling the stochastic level of gene activation.

In many cases, external control over the magnitude and timing of gene activation or repression is desirable.

We observed a near-linear relationship between the amount of sgTetO transfected and the mean fluorescence by FACS (Supplementary information, Figure S4B), indicating that the level of gene activation could be controlled precisely by using CRISPR-on.

The usual approach, Welch knew, would be to look for markers in their cancer cells — to find patterns of gene activation, say, that made some of them dangerous.

Scientists will first have to parse the sequence of gene activation and protein expression that triggers tissue growth from progenitor cells.