Sentence examples for control of complement from inspiring English sources
Interestingly, inactivation of C3b to iC3b on the NP surface did not correlate with NP affinity to factor H, a cofactor for protease factor I that degrades C3b into iC3b, indicating that control of complement protein C3 stability depends on architectural details in addition to factor H affinity.
Our proteomic data suggest that complement regulators are involved in control of complement activation.
The functions of FHR-1 and other factor H-related proteins are poorly understood, but appear to include control of complement activation, cellular adherence and other functions [13], [41] [45].
To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined together with disease-associated genetic markers in AMD patients.
Based on the hypothesis that defective control of complement activation leads to the release of complement cleavage products which are detectable in the circulation, we performed a comprehensive investigation of AP of complement protein plasma concentrations in a cohort of AMD patients and controls.
Moreover, altered complement proteins may have specific local effects such as an impaired control of complement activation at the level of the RPE and Bruch's membrane.
If inadequate control of the complement system caused by genetic predisposition is involved in SLE nephritis, it could become an additional indication for use of the emerging complement inhibitors such as eculizumab, which is a monoclonal antibody inhibiting cleavage and activation of C5.
One important molecule for controlling of the complement cascade is factor H (FH).
For sites close to the brain surface where pial vessels penetrate there was some deposition of AQP4-IgG alone (6/12) and of control IgG + complement (6/13) and – complement (5/10) in the cerebellum.
These inhibitors are typically built of complement control protein (CCP) domains and are mainly encoded by the RCA (regulators of complement activation) gene cluster located on the long arm of chromosome 1.
Now with the Republicans in control of the House complementing Senate Democrats from fossil states, the situation becomes totally impossible.
