Sentence examples for control of commitment from inspiring English sources

Signals elicited by binding of the T cell receptor (TCR) and the CD4/CD8 co-receptor to type I or type II major histocompatibility (MHC /peptide complex determine the positive and negative selection events, as well as the control of commitment towards the differentiation into CD4 or CD8 single positive cells.

By comparing global gene expression in C2C12 cells over-expressing RNase L and in control cells using SAGE Serial Analysiss of Gene Expression) [23] we identified different transcripts that are down-regulated by RNase L. Many of these mRNAs encode key factors implicated in the control of pluripotency, commitment and differentiation of stem cells.

We analyzed the role of p53 in ESC differentiation and found that p53 is an important mediator of p38MAPK-induced control of ESC commitment.

Entry into lineage-specific differentiation from the pluripotent state is pivotal to mammalian development, yet the molecular mechanisms behind control of lineage commitment remain poorly understood.

Interestingly, the proportions of MHC IIhiCD163- and MHC IIhiCD163+ cells remained similar throughout the period of observation, indicating that control of the commitment to differentiation into DCs or Mϕ was unchanged by the presence of autoreactive T cells.

In agreement with this, we find that Tsc1/2 and Rhb1 are involved in the control of mitotic commitment following nitrogen stress in fission yeast, suggesting that an AMPK-Tsc-TORC1 signaling module exists in this model organism.

For C. elegans, the genetic and molecular genetic control of the commitment to develop as dauer larvae is well characterised and includes a TGF-β-like pathway, an insulin-like pathway and a guanyl cyclase pathway [ 13].

David Faulkner, GB Hockey's performance director, said he had taken personal control of athletes' commitments in a bid to mitigate the effects of these distractions.

(Applause) He spoke of environmental problems, urged tougher standards on air and water, the need for population control — "the kind of commitment we have heretofore brought to military operations".

In vivo, the cartilage and chondrocytes are exposed to low oxygen tension (2-72-7%torathen), contributing to the maintenance of the chondrocyte phenotype and to a tight control of the chondrogenic commitment and differentiation of various types of MSCs.

In addition to its well-known role in DNA-damage response, apoptosis, cell cycle control and tumor suppression, p53 has also been involved in vivo in embryonic development; our results show now that p53 mediates, at least for a large part, the p38MAPK control of the early commitment of ESCs toward mesodermal and neural lineages.