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Rudolph, T., Beuch, S. & Reuter, G. Lysine-specific histone demethylase LSD1 and the dynamic control of chromatin.
Grubert, F. et al. Genetic control of chromatin states in humans involves local and distal chromosomal interactions.
However, the mechanisms underlying cytoskeletal control of chromatin remodeling are not well understood.
They find a central role for the LIM homeodomain transcription factor LHX2 in the global control of chromatin accessibility and identify Lhx2-dependent candidate pioneer factors that may contribute to the establishment and maintenance of open chromatin in the retina.
Studying viral control of chromatin modifications is identifying histones as important players in the battle between host and virus for control of cell cycle and gene expression.
These mechanisms are highly conserved across the eukaryotic kingdom although in plants, owing to the maintenance of dedifferentiated cell states that allow for post-embyronic changes in development, strict control of chromatin remodelling is even more paramount.
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This induces a cross-talk between different chromatin modifications that allows the spatio-temporal control of chromatin-associated events.
Such arrays will enable dissection of spatial components that underlie the control of chromatin-templated processes, both on a biophysical and on a biochemical level.
Following this parsimonious model the observed degree of coupling between fluctuations of the mRNA levels in the cells and fluctuations in productive ribosome engagement should be an effect of specific mechanisms of molecular pairing between mRNA steady state determinants (i.e., controls of chromatin remodeling, transcription and mRNA decay) and regulation of translation of the same mRNA.
Waszak, S. M. et al. Population variation and genetic control of modular chromatin architecture in humans.
The sag1 promoter was used as a control of active chromatin [ 14].
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