This finding indicates that the early steps of HCV entry into its target cells involve tight control of CD81 accessibility to the viral particle.
For example, the control of drug accessibility to tumor cells by increasing the efflux of the drug molecules (multidrug resistance) is a major factor in the failure of multiple forms of chemotherapy [22].
Clarification of the contributions of differential rates of trans-splicing, differential mRNA stability, and control of chromatin accessibility for transcription is central to understanding dinoflagellate gene expression.
As with other antigen-specific receptor loci, recombination in the TRB locus is under strict lineage-, stage- and allele-specific regulation associated with control of RAG accessibility to RSs mediated through alterations in chromatin structure (the 'accessibility hypothesis') [ 18- 20].
And while it does reward our brain with a sense of control and ease of accessibility, it's certainly not perfect.
These release numbers can be used to control the degree of accessibility of the data in the 2-DE database.
Since the control of transcription factor accessibility in the region close to the transcription initiation site is often crucial for gene expression, we wondered whether it might be important for the regulation of GABARAPL1 expression.
In this context, chromatin remodeling complexes of the SWI/SNF, ISWI and Mi-2/NuRD families control the accessibility of specific regions of DNA to lineage-specific TFs by regulating chromatin compaction, spacing of nucleosomes, histone DNA contacts, and association with histone modifying enzymes.
Third, these methyl-CpG binding proteins are able to recruit large protein complexes which control the accessibility of DNA through modification of the chromatin structure [ 11].
Elements such as RNA thermometers are structures sensitive to temperature shifts and control the accessibility of the Shine-Dalgarno sequence of the mRNA leader (reviewed in [ 12]).
