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While most nuclear lncRNAs control multiple cellular processes through epigenetic mechanisms, a number of them also exert their function post-transcriptionally by regulating alternative splicing (Fig. 1, mechanism 2) [ 88].
In the map of RhoB regulation pathway, RhoB is a member of small GTPases family and can control multiple cellular processes, including actin and microtubule dynamics, gene expression, cell cycle, cell polarity and membrane transport.
Reported reasons for the current limited complexity in synthetic circuits include too simplistic engineering design principles [ 5], difficulty to independently control multiple cellular processes in parallel [ 7] and increasing problems to construct and test circuits as they get larger [ 8].
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The proteasome is a large intracellular multicatalytic protease found both in the cytoplasm and the nucleus controlling multiple cellular processes (Peters et al, 1994).
Our laboratory has been investigating the membrane-localised activity of nucleoside diphosphate kinase (nm23, NDPK-H1/H2 isoforms; ∼17 kDa) [7 12], a multifunctional, hexameric enzyme that not only regulates the balance of cellular nucleotides such as ATP/ADP and GTP/GDP but also controls multiple cellular processes [13].
The data suggests that complexity mRNA-miRNA interactions participate in miR-206 control of multiple cellular processes.
Receptor tyrosine kinases (RTK) form a family of transmembrane proteins widely conserved in Metazoa, with key functions in cell-to-cell communication and control of multiple cellular processes.
In addition to its primary roles in pHi homeostasis and cell volume regulation, a substantial body of evidence indicates that NHE1 has fundamental roles in control of multiple cellular processes, including cell proliferation, cell death/survival balance, cell mobility, and a wide variety of cell signalling transduction.
BRCA1 is a tumour suppressor gene which is mutated in up to 5 10% of breast cancer cases and is involved in multiple cellular processes including DNA damage control, cell cycle checkpoint control, apoptosis, ubiquitination and transcriptional regulation.
In eukaryotes, protein ubiquitination is a key biochemical mechanism that is involved in multiple cellular processes, from the control of protein levels to the regulation of gene expression [1] [4].
DUBs have been demonstrated to play essential roles in multiple cellular processes other than ubiquitin processing.
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