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Womelsdorf, T., Valiante, T. A., Sahin, N. T., Miller, K. J. & Tiesinga, P. Dynamic circuit motifs underlying rhythmic gain control, gating and integration.
Further, when taken together, our data indicate that despite the radically different physical natures of the stimuli, the actions of all three modalities converge on the parts of K2P2.1 (TREK-1) in which these GOF mutations reside, the extracellular vestibule and the outer M4 region, to control gating.
A kinked helical beam and anchor domain link the Piezo repeats to the pore, and are poised to control gating allosterically.
STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM cytoplasmic domain, control gating of the plasma membrane Ca2+ channel ORAI1.
This protein also makes up the upper part of the tip links that control gating of the mechanoelectrical transduction channels.
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Methods of suspending respiration include active breathing control, gated CT scanning and respiration correlated CT scans.
CNG channels belong to the superfamily of voltage-gated channels, where the motion of the α-helix S6 controls gating in most of its members.
Schewe, M. et al. A non-canonical voltage-sensing mechanism controls gating in K2P K channels.
Barrot, M. et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli.
We refer to this phenomenon as thermally controlled gating.
We have also designed and synthesized redox and photochemically controlled gated hemicarceplexes.
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