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However, the therapeutic effect was not reproduced and no striking differences on clinical signs of EAE were observed in treated versus control diseased animals (unpublished data).
As a proof of concept that DNA methylation in a subset of genomic loci may connect end-stage cardiomyopathy with different etiologies, we set out initially to profile a series of heterogenous cardiomyopathic left ventricles and a single normal control (diseased: samples I, II, III; control: sample A; Table 1) using MeDIP-chip (Method summarised in Figure S1).
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Repeated measures analysis of variance and Student's or Welch's t test were used to evaluate possible differences in staining intensity between normal controls, diseased controls and ALS.
Each dataset consists of an equal number of case (diseased) and control (disease free) subjects.
It is possible to compare, for example, the proteome of control and diseased tissues to identify disease-related differences.
In this technique, two different protein samples (control and diseased) and one internal control (mixture of control and diseased sample in equal proportion) are labelled with any of the three fluorophores: Cy2, Cy3, or Cy5.
This study aimed to investigate BBB transport of L-DOPA transport in conjunction with its intra-brain conversion, in both control and diseased cerebral hemispheres in the unilateral rat rotenone model of Parkinson's disease.
mRNA and protein expression of HCN subunits were measured in both atria and ventricles of control and diseased hearts.
Next we analyzed sex biased gene expression differences in control and diseased human kidneys.
In order to understand the molecular basis of this gender disparity, we examined sex specific gene expression patterns in control and diseased, human and murine kidney samples.
Using geNorm (http://medgen.ugent.be/~jvdesomp/genorm/#PrimerDesign) we determined that of these housekeeping genes, RPLPO was most stable for both control and diseased samples.
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