Most IGT procedures relate to diagnostic and therapeutic interventions such as evacuation/decompression, revascularisation/devascularisation, pain relief, critical life conditions (e.g. acute bleeding) and tumour control (palliative, curative).
In these countries, CHWs were previously recruited (often drawing from a pool of volunteers operating at village level) and provided with basic health training to deliver various services including health promotion, immunisation, family planning, improved infant and young child feeding practices, hygiene, disease control, and curative care.
Moreover, some authors mentioned that neoadjuvant chemotherapy led to local control and allowed curative surgery [16], resulting in long-term survival, whereas the clinical results of these therapies cannot be verified without long survivors.
Patients with fast tumor regression could obtain excellent local control but a curative effect might still not be achieved due to distant metastasis.
As the outcomes for HER2-positive MBC continue to improve, long-term follow-up of these patients to capture prospective treatment patterns, such as in registHER and the subsequent SystHERs registry, are required to develop prognostic models for identification of patients who may expect to experience long-term disease control and potentially curative outcomes.
Controlling rehospitalizations may be one curative prescription to control the bleeding.
Other determinants include the natural force of infection and its seasonal variation, the vaccination coverage which could be achieved, especially in the most exposed and the most vulnerable groups and the efficacy and coverage of other malaria control interventions, preventive or curative.
The control arm maintains existing curative and preventive services without adding any prevention component included in eCROPS-CA except for RRA and DRA.
The services provided by the projects range from ante-natal (91%), post-natal (82%), curative (86%), control of sexually transmitted diseases (77%), well-baby clinics (child health) (68%), family planning (45.5%), and HIV education (36.4%).
A critical step throughout the process is to determine the interaction between pathways that modulate disease and those that modulate symptoms, to ensure that symptom control does not compromise curative benefit.
