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After incubation, the width of the gap (T16 hrs) was measured by Image J. The rate of wound closure (WC) was calculated by the following equation: WC = 1 − (T16 hrs/ T0)∗100% [ 53]; as referring control cells, migration inhibiting rate of treated cells (MIR) = 1 − (WCtreatment/WCcontrol)∗100%.
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Guvakova MA (2007) Insulin-like growth factors control cell migration in health and disease.
We also show the possibility to control cell migration by small pulsed currents.
Wu, Y.C., Tsai, M.C., Cheng, L.C., Chou, C.J. & Weng, N.Y. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
In addition, roles of other kinases that may phosphorylate PDPN to control cell migration have not been investigated.
Elliott et al. use high-resolution imaging, microfabrication and computational analyses to show that the interplay between cell-surface curvature and activity and cortical recruitment of myosin II, control cell migration in 3D matrices.
Before we can use mechanotaxis to control cell migration on a biomaterial surface, quantitative design criteria for a microelasticity gradient should be established.
Changing the local rheology or the nanotextured surface of substrates has proved an efficient approach to improve cell lineage differentiation, to control cell migration properties and to understand environmental sensing processes.
The chapters in this book present readers with the latest protocols to observe, quantify, and control cell migration.
Connecting Ln and α6β4 integrin activates intracellular signaling pathways, such as the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways, which control cell migration, adhesion, and survival [29 31].
Accumulating evidence suggests that MAPKs might also control cell migration, although the precise mechanism remains obscure [23], [24].
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