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Because each contributory gene has a weak effect, none stands out.
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Candidate gene approaches to identify contributory genes are based on prior knowledge of gene protein function.
A fundamental difference between SPI and classical complementation cloning is that the goal is to identify a spectrum of "contributory genes" (or cDNAs), rather than a single entity ("command gene"), which by definition have graded impact on cellular phenotypes.
The heritability of hypertension is thought to range from 30% to 60%, with variable clinical presentation and drug response due to multiple contributory genes, genetic/ethnic heterogeneity and environmental effects [1], [2].
Genes identified by searches for common genetic variants associated with disease have been highly productive in both RA and ankylosing spondylitis, and the effect of targeting the products of such contributory genes may be disproportionately greater than the apparent contribution to syndrome susceptibility.
In the current study, we describe a case study where exome sequencing together with extensive biochemical tests pinpointed the disease-contributory gene for an idiopathic disease that failed to be diagnosed by conventional means.
Due to conflicting results obtained in case-control association studies of complex diseases such as cancer, the current focus is aimed on searching for gene-gene interactions as a key contributory factor in the disease outcome.
Deletions within the neurexin genes represent a contributory factor in both autism and schizophrenia.
Recent data have been demonstrated that mutations in PVRL1, MSX1, TBX22, IRF6 and FGFR1 are responsible for syndromic forms of OFC (5– 9) and that variation within these genes is a contributory factor to their non-syndromic counterparts (10– 10).
To test the hypothesis that a mutation in uridine diphosphate-glucuronosyl transferase 1A1 (Ugene1) gene of breast-fed infants is a contributory factor to prolonged unconjugated hyperbilirubinemia.
This gene retention varied from cell to cell and this is likely to have been a major contributory factor in the divergent evolution of the different yeast that evolved from this ancestral cell.
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