Sentence examples for contributors to the dysfunction from inspiring English sources

Certainly "demographic sorting," partisan news outlets, and north/south and urban/rural divides are among the factors playing significant roles in the current polarized politics but redistricting and the flood of money unleashed by the Supreme Court's ill-advised Citizen United decision are key contributors to the dysfunction that has gripped Washington by the throat.

On the basis of the aforementioned studies, we also hypothesize that the exacerbation of ROS/RNS-mediated responses and endothelial dysfunction are key contributors to the development of mitochondrial dysfunction demonstrated in the current study.

Endothelial dysfunction, whether due to systemic inflammation or some other as yet unknown mediator, is probably a major contributor to the organ dysfunction observed in severe sepsis and is obviously the cause of septic shock.

Mobilization of RTEs is likely to be an important contributor to the progressive dysfunction of aging cells.

We suggest that somatic retrotransposition is a potentially important aging process that can affect many tissues, and that the mobilization of RTEs is likely to be a significant contributor to the progressive dysfunction of aging cells [ 48].

One of the major contributors to the aging process is mitochondrial dysfunction, which involves a decrease in the oxidative phosphorylation efficacy and an increase in the electron leakage resulting in reduced ATP generation [ 17].

Decreased production of adiponectin and/or elevated expression of A-FABP are important contributors to the pathogenesis of obesity-induced endothelial dysfunction and cardiovascular disease.

Insulin resistance and pancreatic β-cell dysfunction are important contributors to the pathogenesis of type 2 diabetes (1– 3).

Insulin resistance and β-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes.

Epithelial cells, a primary site of dysfunction in CF, are major contributors to the inflammatory cascades involved in disease.

Since it is now believed that soluble Aβ polymers are major contributors to the toxicity associated with the peptide [ 45, 46] and soluble Aβ is the primary contributor to cognitive dysfunction in line 85 huAPP/PS1 mice [ 46], we examined Aβ levels in the RIPA insoluble (100,000 × g pellet) and soluble (RIPA supernatant) fractions of the hippocampus of J147-treated and control huAPP/PS1 mice.